Penaeus monodon is one of the most cultivated crustaceans worldwide, with over 500,000 tonnes harvested every year, and the most important traded aquaculture commodity in Asia. Despite being reared for over a century and fairly well studied, many of its biological needs are disregarded in farming, such as spatial requirements and reproductive conditions. In fact, spawning techniques majorly include uni- or bilateral ablation of eyestalks, even though there is evidence that this species spawns without direct manipulation. Stress is also an issue that should be tackled, as poor farming conditions may cause stress and evoke high sensitivity to infections. A slaughter protocol should also be implemented, as stunning and slaughtering are normally performed by immersion in icewater.