Oreochromis niloticus is a very resilient and well-known species to the aquaculture industry. However, it requires a series of features to ensure its welfare in farming conditions. Intensive farming may disrupt natural reproductive cycles and fails to ensure that proper substrate and shelter are provided. Semi-intensive culture respect some spatial and habitat needs, but most industrial farming, especially in floating cages, does not. Although a remarkable amount of research has been conducted, another issue that needs to be tackled is wild-caught fish for feed. This should be replaced by fish slaughterhouse waste and other sources or avoided by extensive farming fully based on sustainable sources.